Throughout its history, compassion has been prominent in the NTD movement. While the eradication of diseases, such as polio and smallpox, has focused almost exclusively on prevention, the goals of NTD elimination are to both interrupt disease transmission and provide care to those already affected. The NTD community also emphasizes human rights approaches in its programming, ensuring that affected persons have a prominent voice in the design and evaluation of programs. Nevertheless, critics have sometimes perceived the NTD community’s efforts as being characterized by ‘pity’ or ‘charity,’ grounded in postcolonial structures, rather than compassion. This GHCR is intended to explore these dimensions of compassion in the NTD community through an impassioned conversation with persons affected by NTDs, NTD experts from around the world, and global public health authorities.