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SISMID 2022 - DAY 1 - Shared screen with speaker view
Khai Tram
05:42:47
is infection-induced mortality == case fatality ratio?
tiggy menkir - harvard (she/her)
05:44:34
@Khai, the former is a rate while the latter is a proportion
Khai Tram
05:45:10
thanks!
tiggy menkir - harvard (she/her)
05:45:15
so the CFR describes the proportion of cases who die, while the disease-induced mortality rate describes the rate of mortality among the infected
tiggy menkir - harvard (she/her)
05:45:17
Of course!
Youngseo Clara Jeong
05:58:57
Does vaccine efficacy describe the case where some proportion of vaccinated individuals are 100% immune and the rest of the population are susceptible; or does it describe the case where every vaccinated individual is some% less likely to be infected?
Youngseo Clara Jeong
05:59:32
I see. Thank you!
tiggy menkir - harvard (she/her)
05:59:38
What you are describing is the distinction between all-or-nothing vs leaky vaccines
Youngseo Clara Jeong
06:01:39
Thanks for the clarification.
Oumar (He/him)
06:27:08
so for all models, "protection from infection" is mode that counts?
Nikhet Chowdhury
06:29:09
If SIR accounts for transmission blocking vaccinations, which type of models accounts for disease-preventing vaccinations?
Oumar (He/him)
06:29:09
thank you for clarifying that. I see that point
Matthew Joseph Ferrari
06:31:28
Nikhet -- that can still be accounted or in an SIR model, or rather a model built upon an SIR model. You could imagine adding a calculation that Q% of individuals going into the I class develop symptomatic disease and a vaccine reduces that by some factor.
Nikhet Chowdhury
06:32:21
thank you!
Matthew Joseph Ferrari
06:32:39
with respect to transmission, the disease state might be redundant with infection, so it doesn't necessarily need to be linked and wouldn't (necessarily) change the SIR equations
Khai Tram
06:34:41
Similarly, in the transplant population (i.e. immunosuppressed), we recommend household members, caregivers, and closer contacts to be vaccinated.
tiggy menkir - harvard (she/her)
06:38:24
@Khai, this is an interesting point you raise! This kind of ring vaccination strategy you describe would be modeled a little differently than vaxx at birth
tiggy menkir - harvard (she/her)
06:38:30
An example here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696719/
Kalongo Hamusonde
06:47:51
How do you determine optimal parameter values for the model ?
Khai Tram
06:49:12
sepsis is not generally considered an infectious disease, though it is caused by a variety of infections. It's more of a constellation of clinical and physiologic sx, inflammatory response to serious infection. Not to confuse things, but you can read about SIRS criteria (no relation to S-I-R models) as it relates to sepsis:tachycardia, fever/hypothermia, leukocytosis
Pam
06:49:21
Would it be possible for all of these citations to be accumulated in a separate document for distribution, in case we lose the chat?
tiggy menkir - harvard (she/her)
06:49:39
Good idea, Pam! Will do 🙂
Pam
06:49:57
Wonderful! Thanks!
Nikhet Chowdhury
06:50:10
Sounds like an awesome project!
tiggy menkir - harvard (she/her)
06:52:51
A relevant paper to Oumar's question: https://www.nature.com/articles/s41591-021-01234-8
Micaela Martinez - Emory University
06:53:03
Hi All, for those of you wanting to save the chat, click on the “…” to the left of the chat window and there should be a save chat option
Oumar (He/him)
06:53:35
Thx Tigist!
Khai Tram
06:56:10
are we in the same groups?
Khai Tram
06:56:18
great
Liza Hadley
06:56:38
I missed the group aspect today - is it ok to join a group from tomorrow?
Matthew Joseph Ferrari
06:56:57
Liza - we will put you a group for tomorrow
Liza Hadley
06:57:03
Brill thanks
Tara Prezioso
06:57:04
same question here
Pam
06:57:32
What's a slide deck?
Tara Prezioso
06:57:41
I think she means ppt
Tara Prezioso
06:57:45
:-)
Maia Tarnas
06:58:55
Thank you!
Yingying Wang JYU
06:59:01
Thanks you
Tara Prezioso
06:59:02
Thank you!
Laura Pasqua Leone
06:59:10
Thank you!